Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.

@article{Jucker2011PathogenicPS,
  title={Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.},
  author={Mathias Jucker and Lary C Walker},
  journal={Annals of neurology},
  year={2011},
  volume={70 4},
  pages={
          532-40
        }
}
The misfolding and aggregation of specific proteins is a seminal occurrence in a remarkable variety of neurodegenerative disorders. In Alzheimer disease (the most prevalent cerebral proteopathy), the two principal aggregating proteins are β-amyloid (Aβ) and tau. The abnormal assemblies formed by conformational variants of these proteins range in size from small oligomers to the characteristic lesions that are visible by optical microscopy, such as senile plaques and neurofibrillary tangles… CONTINUE READING

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