Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

@inproceedings{Kasela2017PathogenicIF,
  title={Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells},
  author={Silva Kasela and Kai Kisand and Liina Tserel and Epp Kaleviste and Anu Remm and Krista Fischer and T{\"o}nu Esko and Harm-Jan Westra and Benjamin Peter Fairfax and Seiko Makino and Julian C. Knight and Lude Franke and Andres Metspalu and P{\"a}rt Peterson and Lili Milani},
  booktitle={PLoS genetics},
  year={2017}
}
Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and inflammatory diseases. Studies on disease-associated genetic polymorphisms have highlighted the importance of biological context for many regulatory variants, which is particularly relevant in understanding the genetic regulation of the immune system and its cellular phenotypes. Here we show cell type-specific regulation of transcript levels of… CONTINUE READING