Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis.

@article{Flynn2004PathogenicHT,
  title={Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis.},
  author={Jeffrey C. Flynn and Daniel J. Mccormick and Vladimir Brusic and Qiang Wan and John C Panos and Alvaro A. Giraldo and Chella S. David and Yi-chi M. Kong},
  journal={Cellular immunology},
  year={2004},
  volume={229 2},
  pages={79-85}
}
To identify pathogenic epitopes on human thyroglobulin (hTg), a homodimer of 660kDa, we have applied a computer-based algorithm to predict potential HLA-DR3-binding peptides and have tested them in DR3-transgenic mice. Of the 39 peptides selected, four stimulated a proliferative response from hTg-primed cells of DR3+ mice, but not DQ8+ mice. Of the four peptides, one, hTg2079, was consistently pathogenic. Thyroiditis was not only produced by adoptive transfer of hTg-primed, hTg2079-activated… CONTINUE READING

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