Pathogenic bone loss in rheumatoid arthritis : mechanisms and therapeutic approaches

@inproceedings{Cantley2009PathogenicBL,
  title={Pathogenic bone loss in rheumatoid arthritis : mechanisms and therapeutic approaches},
  author={Melissa D. Cantley and Malcolm D. Smith and David Haynes},
  year={2009}
}
Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by destruction of the joint, and this has a major impact on its function. Progressive joint destruction is the hallmark feature of RA. The disease is characterized by joint inflammation, synovial hyperplasia and associated destruction of bone and cartilage [1]. It is the most common autoimmune disease in Australia and currently affects 1% of the world’s population [201]. Despite the prevalence of this disease, complete… CONTINUE READING

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NF-kappaB functions in osteoclasts.

Biochemical and biophysical research communications • 2009