Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme.

@article{Lelouard2010PathogenicBA,
  title={Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme.},
  author={Hugues Lelouard and Sandrine Henri and B{\'e}atrice de Bovis and B{\'e}n{\'e}dicte Mugnier and Alexandre Chollat-Namy and Bernard Malissen and St{\'e}phane M{\'e}resse and Jean-Pierre E. Gorvel},
  journal={Gastroenterology},
  year={2010},
  volume={138 1},
  pages={173-84.e1-3}
}
BACKGROUND & AIMS Lysozyme has an important role in preventing bacterial infection. In the gastrointestinal tract, lysozyme is thought to be mainly expressed by Paneth cells of the crypt epithelium. We investigated its expression in the Peyer's patch, a major intestinal site of antigen sampling and pathogen entry. METHODS We performed immunostaining on normal and Salmonella Typhimurium-infected intestinal samples and analyzed them by confocal microscopy and flow cytometry. RESULTS In Peyer… CONTINUE READING
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