Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells.

@article{Zhang2008PathogenicAI,
  title={Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells.},
  author={Jie Zhang and Annett Marita Jacobi and Tao Wang and Betty Diamond},
  journal={Molecular medicine},
  year={2008},
  volume={14 11-12},
  pages={
          675-81
        }
}
Previous studies have shown that both murine and human anti-double-stranded DNA (anti-dsDNA) antibodies can develop from non-DNA-reactive B cells and suggest a crucial role for somatic mutation in dsDNA binding. However, since only a limited number of human anti-dsDNA antibodies have been analyzed previously, we could not exclude other mechanisms for the generation of anti-dsDNA antibodies in patients with systemic lupus erythematosus (SLE). Therefore, we isolated IgM anti-dsDNA antibodies from… CONTINUE READING