Pathogenic anti-desmoglein MAbs show variable ELISA activity because of preferential binding of mature versus proprotein isoforms of desmoglein 3.

TO THE EDITOR The desmosomal cadherins desmoglein (DSG) 3 and DSG1 are targets of autoantibodies in the potentially fatal blistering disease, pemphigus vulgaris (PV) (Stanley and Amagai, 2006). DSGs are synthesized as preproproteins, which are processed first in the endoplasmic reticulum to remove the signal sequence and subsequently by the Golgi proprotein… CONTINUE READING