Pathogenic T helper 1 cells reach the brain before T helper 17 cells, and T regulatory cells suppress them albeit incompletely

Abstract

Bordetella pertussis toxin [5], which are two major stimulators of innate immunity. Lowther and colleagues [14] determined that th1, not th17, t cells reach the brain first and mediate the early phases of clinical disease. How does this relate to multiple sclerosis? In multiple sclerosis there is evidence of both th1 and th17 t cells in lesions [13, 21… (More)
DOI: 10.1007/s00401-013-1180-z

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