Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of Hepatitis

@inproceedings{Arshad2013PathogenicMH,
  title={Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of Hepatitis},
  author={Muhammad Imran Arshad and Sol{\'e}ne Patrat-Delon and Claire Piquet-Pellorce and Annie L’Helgoualc’h and Michel Rauch and Valentine Genet and Catherine Lucas-Clerc and Christian Bleau and Lucie Lamontagne and Michel Samson},
  booktitle={PloS one},
  year={2013}
}
The IL-33/ST2 axis is known to be involved in liver pathologies. Although, the IL-33 levels increased in sera of viral hepatitis patients in human, the cellular sources of IL-33 in viral hepatitis remained obscure. Therefore, we aimed to investigate the expression of IL-33 in murine fulminant hepatitis induced by a Toll like receptor (TLR3) viral mimetic, poly(I:C) or by pathogenic mouse hepatitis virus (L2-MHV3). The administration of poly(I:C) plus D-galactosamine (D-GalN) in mice led to… CONTINUE READING

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