Pathogenic Helicobacter pylori Strains Translocate DNA and Activate TLR9 via the Cancer-Associated cag Type IV Secretion System

@inproceedings{Varga2016PathogenicHP,
  title={Pathogenic Helicobacter pylori Strains Translocate DNA and Activate TLR9 via the Cancer-Associated cag Type IV Secretion System},
  author={Matthew Gordon Varga and Carrie L. Shaffer and Johanna Carolina Sierra and Giovanni Dell ’ Ariccia Luc Laeven Gustavo Suarez and M Blanca Piazuelo and Morgan E. Whitaker and Judith Romero-Gallo and Uma S. Krishna and Alberto G. Delgado and Mart{\'i}n Alonso G{\'o}mez and James A. D. Good and Fredrik Almqvist and Eric P Skaar and Pelayo Correa and Keith Wilson and Maria Hadjifrangiskou and Richard M Peek},
  booktitle={Oncogene},
  year={2016}
}
Helicobacter pylori (H. pylori) is the strongest identified risk factor for gastric cancer, the third most common cause of cancer-related death worldwide. An H. pylori constituent that augments cancer risk is the strain-specific cag pathogenicity island, which encodes a type IV secretion system (T4SS) that translocates a pro-inflammatory and oncogenic protein, CagA, into epithelial cells. However, the majority of persons colonized with CagA+ H. pylori strains do not develop cancer, suggesting… CONTINUE READING