Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β‐Protein Precursor

@article{Nostrand2002PathogenicEO,
  title={Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid $\beta$‐Protein Precursor},
  author={William E. Van Nostrand and Jerry P. Melchor and Galina Romanov and K Kristine Zeigler and Judianne Davis},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={977}
}
Abstract: Cerebral amyloid β‐protein angiopathy (CAA) is a key pathological feature of patients with Alzheimer's disease and certain related disorders. Several mutations have been identified within the Aβ region of the Aβ protein precursor (AβPP) gene that appear to enhance the severity of CAA. A new mutation has been identified within the Aβ region (D23N) of AβPP that is associated with severe CAA in an Iowa kindred. Recently, we showed that E22Q Dutch, D23N Iowa, and E22Q/D23N Dutch/Iowa… 
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