Pathogenetical and Clinical Aspects of Antisperm Immunity

@inproceedings{Dondero1999PathogeneticalAC,
  title={Pathogenetical and Clinical Aspects of Antisperm Immunity},
  author={Franco Dondero and Loredana Gandini and Francesco Lombardo and Antonio Filippini and Paolo Lauretti and Elio Ziparo and Andrea Lenzi},
  year={1999}
}
Antisperm antibodies (ASA) have various possible levels of interference to impair the fertilizing capacity of human spermatozoa. In the semen, it has been demonstrated that ASA can induce the formation of spermagglutination and that they also have a negative effect on sperm motility and, after intra-vaginal ejaculation, on their ability to migrate through female genital secretions. ASA can also interfere with the fusion of the gametes, which is the key event of fecundation. The evidence… 
2 Citations
Control and impairment of immune privilege in the testis and in semen.
TLDR
An understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens can escape the immune system in both the male and female genital tracts.
Soluble forms of Fas and Fas ligand concentrations in the seminal plasma of infertile men with varicocele.
TLDR
The sFas concentration in seminal plasma shows a strong association with spermatogenesis, and may be responsible for increased apoptosis induced by the Fas system, resulting in impaired sperMatogenesis in patients with varicocele.

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