Pathogenetical and Clinical Aspects of Antisperm Immunity

  title={Pathogenetical and Clinical Aspects of Antisperm Immunity},
  author={Franco Dondero and Loredana Gandini and Francesco Lombardo and Antonio Filippini and Paolo Lauretti and Elio Ziparo and Andrea Lenzi},
Antisperm antibodies (ASA) have various possible levels of interference to impair the fertilizing capacity of human spermatozoa. In the semen, it has been demonstrated that ASA can induce the formation of spermagglutination and that they also have a negative effect on sperm motility and, after intra-vaginal ejaculation, on their ability to migrate through female genital secretions. ASA can also interfere with the fusion of the gametes, which is the key event of fecundation. The evidence… 
2 Citations
Control and impairment of immune privilege in the testis and in semen.
An understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens can escape the immune system in both the male and female genital tracts.
Soluble forms of Fas and Fas ligand concentrations in the seminal plasma of infertile men with varicocele.
The sFas concentration in seminal plasma shows a strong association with spermatogenesis, and may be responsible for increased apoptosis induced by the Fas system, resulting in impaired sperMatogenesis in patients with varicocele.


Immunobiology of male infertility.
If the antisperm autoimmune reaction represents the casual factor of infertility, corticosteroid therapy seems to give the most satisfactory results, administered either in high doses for a very short time period or in low doses over a prolonged period, or even after transient pharmacologically induced azoospermia.
Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility.
ICSI should be the primary choice for patients who have high numbers of antisperm antibodies present in their semen, and fertilization, embryo development and pregnancy rates after ICSI are not influenced significantly by the proportion of antis sperm antibody-bound spermatozoa, nor by the dominant type of antibodies present.
Failure of sperm-induced immunosuppression: association with antisperm antibodies in women.
  • S. Witkin
  • Medicine, Biology
    American journal of obstetrics and gynecology
  • 1989
Effect of antispermatozoal antibodies in seminal plasma upon spermatozoal function.
The indirect immunobead test for antispermatozoal antibodies of the class IgA, IgG and IgM was applied to the seminal plasma of male partners of infertile couples. The presence of both IgA and IgG
Immunosuppressive activities in the seminal plasma of infertile men: relationship to sperm antibodies and autoimmunity.
The data indicate that T-lymphocyte inhibition by human seminal plasma is due to multiple factors, and reduced amounts of these factors may contribute to the development and/or persistence of sperm autoimmunity in infertile men; however, differences in polyamine substrates available for oxidation in semen do not appear to be a major contributing factor.
Characteristics of anti-spermatozoal antibodies responsible for the shaking phenomenon with special regard to immunoglobulin class and antigen-reactive sites.
Investigations indicate that antispermatozoal IgA in semen and in cervical mucus is probably responsible for the "Shaking phenomenon" in the SCMC-test and for the reduced penetration of spermatozoa into cervical mucUS.