Pathogenetic mechanisms of amyloid A amyloidosis.

  title={Pathogenetic mechanisms of amyloid A amyloidosis.},
  author={J Paul Simons and Raya Al-Shawi and Stephan Ellmerich and Ivana Speck and Samrina Aslam and Winston L. Hutchinson and Palma Patrizia Mangione and Petra Disterer and Janet Anne Gilbertson and Toby Hunt and David J. Millar and Shane S Minogue and Karl Bodin and Mark B Pepys and Philip N. Hawkins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 40},
Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflammation before presenting, most commonly with renal involvement. Using dose-dependent, doxycycline-inducible transgenic expression of SAA in mice, we show that AA amyloid deposition… CONTINUE READING

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