Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

@article{Voulgarelis2010PathogeneticMI,
  title={Pathogenetic mechanisms in the initiation and perpetuation of Sj{\"o}gren's syndrome},
  author={Michael Voulgarelis and Athanasios G. Tzioufas},
  journal={Nature Reviews Rheumatology},
  year={2010},
  volume={6},
  pages={529-537}
}
Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the function of exocrine glands. The involvement of these glands is characterized by focal, mononuclear cell infiltrates that surround the ducts and replace the secretory units. The pathogenetic mechanisms of this autoimmune exocrinopathy have not been fully elucidated. Immunologically-activated or apoptotic glandular epithelial cells that expose autoantigens in genetically predisposed individuals might drive… 
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