Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

@article{Voulgarelis2010PathogeneticMI,
  title={Pathogenetic mechanisms in the initiation and perpetuation of Sj{\"o}gren's syndrome},
  author={Michael Voulgarelis and Athanasios G. Tzioufas},
  journal={Nature Reviews Rheumatology},
  year={2010},
  volume={6},
  pages={529-537}
}
Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the function of exocrine glands. The involvement of these glands is characterized by focal, mononuclear cell infiltrates that surround the ducts and replace the secretory units. The pathogenetic mechanisms of this autoimmune exocrinopathy have not been fully elucidated. Immunologically-activated or apoptotic glandular epithelial cells that expose autoantigens in genetically predisposed individuals might drive… 
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Pathogenetic Mechanisms Implicated in Sjögren’s Syndrome Lymphomagenesis: A Review of the Literature
TLDR
Sjögren’s Syndrome is a chronic autoimmune disorder characterized by focal mononuclear cell infiltrates that surround the ducts of the exocrine glands, impairing the function of their secretory units, leading to increased morbidity and mortality rates.
Dysregulation of Adaptive Immunity in Sjögren’s Syndrome
  • Qing Yu
  • Medicine, Biology
    Sjögren's Syndrome and Oral Health
  • 2021
TLDR
Findings from both human samples and mouse disease models have convincingly demonstrated that T and B lymphocytes, the chief cellular players of adaptive immune system cooperatively induce, amplify and sustain SjS disease pathologies through the effector molecules they produce, including cytokines and autoantibodies.
A comprehensive review of autoantibodies in primary Sjögren's syndrome: clinical phenotypes and regulatory mechanisms.
T Cell-Associated Cytokines in the Pathogenesis of Sjögren's Syndrome.
  • Jun-O Jin, Qing Yu
  • Biology, Medicine
    Journal of clinical & cellular immunology
  • 2013
TLDR
The recent findings on the expression and functions of cytokines in this disease are summarized, with specific focus on those derived from T cells and/or directly affecting T cell responses.
Emerging avenues linking inflammation, angiogenesis and Sjögren's syndrome.
The Multiple Roles of B Cells in the Pathogenesis of Sjögren’s Syndrome
TLDR
An overview of recent advances in the identification of pathogenic B cell subsets and Breg cells, as well as new development of B-cell targeted therapies in pSS patients are provided.
B-cell hyperactivity in primary Sjögren's syndrome
TLDR
New insights in the role of B cells in the pathogenetic process of pSS offer ample targets for successful therapeutical intervention in pSS.
Clinical and immunological parameters of Sjögren's syndrome.
B cell dysregulation in primary Sjögren’s syndrome: A review
Unique Phenotypes and Functions of Follicular Helper T Cells and Regulatory T Cells in Sjögren’s Syndrome
TLDR
This review of recent publications focused on follicular helper T cells related to antibody production and regulatory T cells to control immune tolerance in the pathogenesis of Sjogren’s syndrome.
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References

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TLDR
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TLDR
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