Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.


Derangement of the nuclear factor κB (NF-κB) pathway initiates and/or sustains many types of human cancer. B-cell malignancies are particularly affected by oncogenic mutations, translocations, and copy number alterations affecting key components the NF-κB pathway, most likely owing to the pervasive role of this pathway in normal B cells. These genetic… (More)
DOI: 10.1111/j.1600-065X.2012.01105.x


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