Pathogenetic concepts of acute coronary syndromes.

  title={Pathogenetic concepts of acute coronary syndromes.},
  author={Roberto Corti and Valentin Fuster and Juan Jose Badimon},
  journal={Journal of the American College of Cardiology},
  volume={41 4 Suppl S},
The propensity of plaque to disrupt is a major determinant of future ischemic events. Although they are distinct from one another, the atherosclerotic and thrombotic processes appear to be interdependent and may be integrated under the term "atherothrombosis." It is now clear that plaque composition, rather than the percent stenosis, is a major determinant of plaque vulnerability. Plaque disruption seems to depend on both passive and active phenomena and is not purely mechanical. Inflammation… CONTINUE READING
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