Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus.

@article{Gutzmer2011PathogeneticAT,
  title={Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus.},
  author={Ralf Gutzmer and Maria Gschwandtner and Kristine Rossbach and Susanne Mommert and Thomas T Werfel and Manfred Kietzmann and Wolfgang B{\"a}umer},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={985-94}
}
Chronic inflammatory skin diseases such as atopic dermatitis (AD) are clinically characterized by erythematous and pruritic skin lesions, immunologically mediated by an inflammatory infiltrate consisting of T-cells, antigen presenting cells (APC) and eosinophilic granulocytes. Histamine levels are increased in lesions of inflammatory skin diseases. It is likely that histamine also plays a pathogenetic role since various relevant cell types such as T-cells and APC express functional histamine… CONTINUE READING
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Histamine H4 receptor activation on human 6-sulfo LacNAc-expressing dendritic cells downregulates their proinflammatory capacity

  • M Gschwandtner, K Schäkel, T Werfel, R Gutzmer
  • Immunology in press
  • 2010

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