Pathogenetic and clinical implications of non-immunoglobulin ; BCL6 translocations in B-cell non-Hodgkin's lymphoma.

@article{Ohno2006PathogeneticAC,
  title={Pathogenetic and clinical implications of non-immunoglobulin ; BCL6 translocations in B-cell non-Hodgkin's lymphoma.},
  author={Hitoshi Ohno},
  journal={Journal of clinical and experimental hematopathology : JCEH},
  year={2006},
  volume={46 2},
  pages={43-53}
}
  • Hitoshi Ohno
  • Published 2006 in
    Journal of clinical and experimental…
Chromosomal translocations affecting band 3q27, where BCL6 gene is located, are among the most common genetic abnormalities in non-Hodgkin's lymphoma of B-cell type (B-NHL). The BCL6 gene encodes a BTB/POZ zinc finger transcription factor, which exerts repressive activity by recruiting corepressor molecules. The 3q27/BCL6 translocation is unique in that it can involve not only immunoglobulin (Ig) genes but also non-Ig chromosomal loci as a partner. To date, around 20 non-Ig partner genes have… CONTINUE READING

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