Pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome.

@article{Settergren1997PathogeneticAC,
  title={Pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome.},
  author={B O Settergren and Clas Ahlm and Oleg A Alexeyev and J. Billheden and B. G. Stegmayr},
  journal={Renal failure},
  year={1997},
  volume={19 1},
  pages={1-14}
}
Hemorrhagic fever with renal syndrome is the most common clinical manifestation of hantavirus infection. The main target organ is the kidney, resulting in an interstitial hemorrhagic nephritis and sometimes acute tubular necrosis. The pathogenesis is still largely unknown, but several recent studies indicate an important role for immune mechanisms including increased expression of cytokines, for example, tumor necrosis factor. Immunohistochemical studies of kidney biopsies have revealed… CONTINUE READING

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