Pathogenetic Implications of BRAF Mutation Distribution in Stage IV Melanoma Patients.


BACKGROUND BRAF mutation frequencies in melanoma subtypes have clinical implications and offer pathogenetic clues. OBJECTIVES To characterize BRAF mutation status in melanoma of unknown primary (MUP) patients, in histological melanoma subtypes and by localization of primary tumors. METHODS In 179 patients with stage IV metastatic melanoma, BRAF mutation… (More)
DOI: 10.1159/000381849