Pathogenesis of virus-induced immune-mediated demyelination.

  title={Pathogenesis of virus-induced immune-mediated demyelination.},
  author={Byung Soo Kim and Michael A. Lyman and Bong Su Kang and Hee Kap Kang and Hwan Goo Lee and Mani Mohindru and J. Prisco Palma},
  journal={Immunologic research},
  volume={24 2},
Theiler's murine encephalomyelitis virus-induced demyelinating disease has been extensively studied as an attractive infectious model for human multiple sclerosis. Virus-specific inflammatory Th1 cell responses followed by autoimmune responses to myelin antigens play a crucial role in the pathogenic processes leading to demyelination. Antibody and cytotoxic T cells (CTL) responses to virus appears to be primarily protective from demyelinating disease. Although the role of Th1 and CTL responses… CONTINUE READING
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