Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host

@article{Hober2010PathogenesisOT,
  title={Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host},
  author={Didier Hober and Pierre Sauter},
  journal={Nature Reviews Endocrinology},
  year={2010},
  volume={6},
  pages={279-289}
}
Enteroviruses are believed to contribute to the pathogenesis of type 1 diabetes mellitus (T1DM). In this Review, the interplay between infection with enteroviruses, the immune system and host genes is discussed. Data from retrospective and prospective epidemiological studies strongly suggest the involvement of enteroviruses, such as coxsackievirus B, in the development of T1DM. Enteroviral RNA and/or proteins can be detected in tissues of patients with T1DM. Isolation of coxsackievirus B4 from… CONTINUE READING
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