Pathogenesis of thrombotic microangiopathy: insights from animal models.

  title={Pathogenesis of thrombotic microangiopathy: insights from animal models.},
  author={Anna Richards and David Kavanagh},
  journal={Nephron. Experimental nephrology},
  volume={113 4},
Animal models are important experimental tools for investigating the molecular mechanisms, environmental and genetic susceptibilities underlying the development of thrombotic microangiopathies. Large mammal, small animal models, knockout, transgenic and conditional knockout mouse models are available to investigate haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura and vascular endothelial growth factor-associated thrombotic microangiopathy. These models have shown that it is… CONTINUE READING


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