Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization.

@article{Lagan2008PathogenesisOT,
  title={Pathogenesis of the systemic inflammatory syndrome and acute lung injury: role of iron mobilization and decompartmentalization.},
  author={Anna L. Lagan and Daniel D. Melley and Timothy W. Evans and Gregory J. Quinlan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={294 2},
  pages={
          L161-74
        }
}
Changes in iron homeostatic responses routinely accompany infectious or proinflammatory insults. The systemic inflammatory response syndrome (SIRS) and the development of acute lung injury (ALI) feature pronounced systemic and lung-specific alterations in iron/heme mobilization and decompartmentalization; such responses may be of pathological significance for both the onset and progression of acute inflammation. The potential for excessive iron-catalyzed oxidative stress, altered… CONTINUE READING
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