Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents.

@article{Maignien1999PathogenesisOT,
  title={Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents.},
  author={Thomas Maignien and Corinne Ida Lasm{\'e}zas and Vincent B{\'e}ringue and Dominique Dormont and J. P. Deslys},
  journal={The Journal of general virology},
  year={1999},
  volume={80 ( Pt 11)},
  pages={3035-42}
}
Transmissible spongiform encephalopathies can be transmitted via the oral route. The understanding of this mode of contamination has become a major issue since it is responsible for the appearance of bovine spongiform encephalopathy (BSE) and is probably implicated in new variant Creutzfeldt-Jakob disease. In this study, we addressed the questions of the propagation pathway and the strain specificity of the pathogenesis of oral contamination of mice with the C506M3 scrapie strain and the 6PB1… CONTINUE READING