Pathogenesis of the antiphospholipid syndrome: an additional example of the mosaic of autoimmunity.

The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by an adaptive immune response against self-PL-binding proteins ending in the production of specific autoantibodies. Antiphospholipid antibodies (aPL; and in particular anti-beta2 glycoprotein I antibodies) are formal diagnostic markers and pathogenic antibodies. Although APS… CONTINUE READING