Pathogenesis of systemic lupus erythematosus.

  title={Pathogenesis of systemic lupus erythematosus.},
  author={Alfred D. Steinberg and Dennis M Klinman},
  journal={Rheumatic diseases clinics of North America},
  volume={14 1},
SLE is a syndrome characterized by diverse clinical signs and symptoms, including rash, serositis, nephritis, central nervous system disease, thrombocytopenia, and leukopenia. These and other manifestations are present in patients with immune abnormalities indicative of B cell hyperactivity: hypergammaglobulinemia, increased amounts of antibodies reactive with self-determinants (characteristically including nuclear antigens), and increased numbers of circulating antibody-producing cells. It is… CONTINUE READING
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