Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease.

@article{Overk2014PathogenesisOS,
  title={Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease.},
  author={Cassia Rose Overk and Eliezer Masliah},
  journal={Biochemical pharmacology},
  year={2014},
  volume={88 4},
  pages={508-16}
}
Considerable progress has been made in the past few years in the fight against Alzheimer's disease (AD) and Parkinson's disease (PD). Neuropathological studies in human brains and experimental in vivo and in vitro models support the notion that synapses are affected even at the earliest stages of the neurodegenerative process. The objective of this manuscript is to review some of the mechanisms of synaptic damage in AD and PD. Some lines of evidence support the notion that oligomeric neurotoxic… CONTINUE READING
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