Pathogenesis of spinally mediated hyperalgesia in diabetes.

  title={Pathogenesis of spinally mediated hyperalgesia in diabetes.},
  author={Khara M. Ramos and Yun Jiang and Camilla I. Svensson and Nigel A. Calcutt},
  volume={56 6},
Hyperalgesia to noxious stimuli is accompanied by increased spinal cyclooxygenase (COX)-2 protein in diabetic rats. The present studies were initiated to establish causality between increased spinal COX-2 activity and hyperalgesia during diabetes and to assess the potential involvement of polyol pathway activity in the pathogenesis of spinally mediated… CONTINUE READING