Pathogenesis of skin lesions caused by sulfur mustard.

  title={Pathogenesis of skin lesions caused by sulfur mustard.},
  author={Robert F. Vogt and Arthur M. Dannenberg and Brian H. Schofield and Noreen A. Hynes and Bruno Papirmeister},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={4 2 Pt 2},
Sulfur mustard (SM) (di-2-chlorethyl sulfide), used for chemical warfare in World War I, is a highly reactive radiomimetic alkylating agent. When applied to the skin of rabbits and guinea pigs, it produced vascular leakage, leukocyte infiltration, and slow death of basal epidermal cells. Thirty to sixty minutes after exposure to SM, injury to the superficial microvasculature (beneath the SM application site) was detected by measuring vascular leakage with Evans blue dye and also with… CONTINUE READING