Pathogenesis of severe acute respiratory syndrome.

  title={Pathogenesis of severe acute respiratory syndrome.},
  author={Yu Lung Lau and Joseph Sriyal Malik Peiris},
  journal={Current opinion in immunology},
  volume={17 4},
Severe acute respiratory syndrome (SARS) is a zoonotic infectious disease caused by a novel coronavirus (CoV). The tissue tropism of SARS-CoV includes not only the lung, but also the gastrointestinal tract, kidney and liver. Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus. There is a prominent innate immune response to SARS-CoV infection, including acute-phase… CONTINUE READING


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