Pathogenesis of retinoic acid-induced abnormal pad patterns on mouse volar skin.

@article{Mori2000PathogenesisOR,
  title={Pathogenesis of retinoic acid-induced abnormal pad patterns on mouse volar skin.},
  author={Naoki Mori and Mizuyo H Tsugane and Kyoko Yamashita and Yoshiaki Ikuta and Masahiro Yasuda},
  journal={Teratology},
  year={2000},
  volume={62 4},
  pages={181-8}
}
BACKGROUND Abnormal dermatoglyphs on human volar skin have been reported in many syndromes, but little is known about the pathogenesis. Patterns of pads on rodent limb volar skin are homologous to human dermatoglyphs. METHODS In previous studies, we showed that transplacental exposure to teratogens induced abnormal pads in mouse fetuses. Moreover, teratogens caused abnormal pad patterns at levels below those that caused skeletal malformations. In this study, we examined morphology and… CONTINUE READING

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