Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.

@article{Lipa2010PathogenesisOR,
  title={Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.},
  author={Joan Lipa and Wei Qiu and N Huang and Benjamin A Alman and C. Y. Amy Pang},
  journal={Plastic and reconstructive surgery},
  year={2010},
  volume={125 2},
  pages={437-45}
}
BACKGROUND Capsular contracture is the main complication in postmastectomy tissue expander and implant breast reconstruction in patients requiring radiotherapy. There is evidence that the wingless signaling pathway plays a central role in the pathogenesis of fibroproliferation in fibromatosis and hyperplastic skin wounds, involving multiple linked events leading to up-regulation of target genes and fibroproliferation. Here, the authors tested their hypothesis that the wingless signaling pathway… CONTINUE READING

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Skin reducing mastectomy and immediate reconstruction: the effect of radiotherapy on complications and patient reported outcomes.

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Smad3 as a mediator of the fibrotic response.

International journal of experimental pathology • 2004

Caught up in a Wnt storm: Wnt singaling in cancer

RH Giles, JH van Es, H. Clevers
Biochim Biophys Acta 2003;1653:1 • 2003

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