Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.

  title={Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.},
  author={Joan Lipa and Wei Qiu and N Huang and Benjamin A Alman and C. Y. Amy Pang},
  journal={Plastic and reconstructive surgery},
  volume={125 2},
BACKGROUND Capsular contracture is the main complication in postmastectomy tissue expander and implant breast reconstruction in patients requiring radiotherapy. There is evidence that the wingless signaling pathway plays a central role in the pathogenesis of fibroproliferation in fibromatosis and hyperplastic skin wounds, involving multiple linked events leading to up-regulation of target genes and fibroproliferation. Here, the authors tested their hypothesis that the wingless signaling pathway… CONTINUE READING


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