Pathogenesis of rabies.

  title={Pathogenesis of rabies.},
  author={Bernhard Dietzschold and Matthias J Schnell and Hilary Koprowski},
  journal={Current topics in microbiology and immunology},
Rabies is a central nervous system (CNS) disease that is almost invariably fatal. The causative agent is rabies virus (RV), a negative-stranded RNA virus of the rhabdovirus family. RV pathogenesis, like that of other viruses, is a multigenic trait. Recent findings indicate that in addition to the RV G protein viral elements that regulate gene expression, especially expression of the L gene, are also likely to play a role in RV pathogenesis. In vivo, RV infects almost exclusively neurons, and… CONTINUE READING

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