Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned

@article{Major2018PathogenesisOP,
  title={Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned},
  author={E. Major and T. Yousry and D. Clifford},
  journal={The Lancet Neurology},
  year={2018},
  volume={17},
  pages={467-480}
}
  • E. Major, T. Yousry, D. Clifford
  • Published 2018
  • Medicine
  • The Lancet Neurology
  • Progressive multifocal leukoencephalopathy (PML) is a rare, devastating demyelinating disease of the CNS caused by the JC virus (JCV) that occurs in patients with compromised immune systems. Detection of PML in systemically immunocompetent patients with multiple sclerosis treated with natalizumab points to a role for this drug in the pathophysiology of PML. Emerging knowledge of the cellular and molecular biology of JCV infection and the pathogenesis of PML-including interplay of this common… CONTINUE READING

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