Pathogenesis of prion diseases: current status and future outlook

@article{Aguzzi2006PathogenesisOP,
  title={Pathogenesis of prion diseases: current status and future outlook},
  author={Adriano Aguzzi and Mathias Heikenwalder},
  journal={Nature Reviews Microbiology},
  year={2006},
  volume={4},
  pages={765-775}
}
The prion, a conformational variant of a host protein, is the infectious particle responsible for transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals. The principal target of prion pathology is the brain, yet most TSEs also display prion replication at extra-cerebral locations, including secondary lymphoid organs and sites of chronic inflammation. Despite significant progress in our understanding of this infectious agent, many fundamental… CONTINUE READING

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