Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein

  title={Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein},
  author={Julie Lotharius and Patrik Brundin},
  journal={Nature Reviews Neuroscience},
Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent developments have shed light on the pathogenic mechanisms that underlie the degeneration of these cells… CONTINUE READING