Pathogenesis of pancreatic cancer: lessons from animal models.

  title={Pathogenesis of pancreatic cancer: lessons from animal models.},
  author={Lewis Charles Murtaugh},
  journal={Toxicologic pathology},
  volume={42 1},
The past several decades have seen great effort devoted to mimicking the key features of pancreatic ductal adenocarcinoma (PDAC) in animals and have produced 2 robust models of this deadly cancer. Carcinogen-treated Syrian hamsters develop PDAC with genetic lesions, which reproduce those of human, including activation of the Kras oncogene, and early studies in this species validated nongenetic risk factors for PDAC including pancreatitis, obesity, and diabetes. More recently, PDAC research has… CONTINUE READING
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