Pathogenesis of oral submucous fibrosis.

  title={Pathogenesis of oral submucous fibrosis.},
  author={Saba Khan and Laxmikanth Chatra and Shenai K Prashanth and K M Veena and P. Mallikarjuna Rao},
  journal={Journal of cancer research and therapeutics},
  volume={8 2},
Data from recent epidemiological studies provide overwhelming evidence that areca nut is the main etiological factor for oral submucous fibrosis (OSF). It is logical to hypothesize that the increased collagen synthesis or reduced collagen degradation is the possible mechanism in the development of the disease. There are numerous biological pathways involved… CONTINUE READING