Pathogenesis of non-insulin-dependent diabetes mellitus in the black population of southern Africa.

@article{Joffe1992PathogenesisON,
  title={Pathogenesis of non-insulin-dependent diabetes mellitus in the black population of southern Africa.},
  author={Barry Isaac Joffe and Vanessa R. Panz and Jeffrey Wing and Frederick Johan Raal and Harold C. Seftel},
  journal={Lancet},
  year={1992},
  volume={340 8817},
  pages={460-2}
}
Non-insulin-dependent diabetes mellitus (NIDDM) is an important health problem in the black population of southern Africa. Whether the primary cause of NIDDM is insulin secretory dysfunction or peripheral insulin resistance is unknown. In westernised populations it is believed that insulin resistance and hyperinsulinaemia occur in the early stages of disease, followed later by progressive impairment of insulin secretion. However, we suggest that in the southern African black population a… CONTINUE READING
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