Pathogenesis of non-alcoholic steatohepatitis: human data.

  title={Pathogenesis of non-alcoholic steatohepatitis: human data.},
  author={John M Edmison and Arthur Joseph McCullough},
  journal={Clinics in liver disease},
  volume={11 1},
  pages={75-104, ix}
Non-alcoholic fatty liver disease (NAFLD) has moved rapidly to the forefront of clinical disease, with a prevalence of 30% in the adult United States population and a definite but yet uncertain rate of progression to cirrhosis and end-stage liver disease. This disease has an impact on all areas of clinical medicine, with increasing prevalence and adversity. It is essential to understand the pathophysiologic mechanisms involved in NAFLD, so that therapeutic strategies can be developed. Although… CONTINUE READING