Pathogenesis of nodular goiter and its implications for surgical management.

  title={Pathogenesis of nodular goiter and its implications for surgical management.},
  author={J{\"u}rg Teuscher and Hans J. Peter and Hans J Gerber and Rudolf Berchtold and Hugo Studer},
  volume={103 1},
Despite sufficient iodine supply, goiter continues to be of considerable surgical significance in formerly endemic countries. It now appears that iodine deficiency and increased thyrotropin stimulation are not the only causes of goiter. Xenotransplantation of human thyroid tissue onto nude mice allowed study of the regulation of growth and function in human goiter tissue. Grafts of human thyroid tissue growing in nude mice could be shown to react to endogenous mouse thyrotropic stimulation and… CONTINUE READING

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