Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome.

@article{Burks2006PathogenesisON,
  title={Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome.},
  author={Eric J Burks and Thomas P. Loughran},
  journal={Blood reviews},
  year={2006},
  volume={20 5},
  pages={245-66}
}
T-cell large granular lymphocyte leukemia (TLGL) is an atypical chronic lymphoproliferative disorder derived from cytotoxic T-cells (CTL). Unlike most forms of leukemia, the pattern of bone marrow infiltration in TLGL may be subtle and the cytopenias are often lineage specific, with neutropenia dominating. Both granulocytic survival and proliferation defects are observed and are mediated by humoral and cell-mediated mechanisms respectively. Splenic production of immune complexes induces a… CONTINUE READING
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