Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNF alpha.

@article{Sarno2000PathogenesisON,
  title={Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNF alpha.},
  author={Euzenir Nunes Sarno and Adalberto Rezende Santos and M{\'a}rcia Rodrigues Jardim and Philip Noel Suffys and Alexandre S. Almeida and Jos{\'e} Augusto da Costa Nery and L M Vieira and Elisabeth P. Sampaio},
  journal={Leprosy review},
  year={2000},
  volume={71 Suppl},
  pages={S154-8; discussion S158-60}
}
Studies carried out over the last decade have strongly suggested that TNF alpha both overtly participates in the cell-mediated immune response against Mycobacterium leprae, and is overproduced during reaction. In addition, reactions are intimately related to the onset of nerve damage. Finally, TNF alpha has been implicated in the pathogenesis of many human and experimental autoimmune peripheral neuropathies that, as in leprosy, result in demyelination and axonal lesions. Because of recent… CONTINUE READING