Pathogenesis of myelofibrosis: role of ineffective megakaryopoiesis and megakaryocyte components.

@article{CastroMalaspina1984PathogenesisOM,
  title={Pathogenesis of myelofibrosis: role of ineffective megakaryopoiesis and megakaryocyte components.},
  author={Hugo Castro-Malaspina},
  journal={Progress in clinical and biological research},
  year={1984},
  volume={154},
  pages={427-54}
}
The pathological and ultrastructural features of the bone marrow and the kinetics of megakaryopoiesis in patients with primary myelofibrosis indicate that a vast number of developing megakaryocytes die within the bone marrow (ineffective megakaryopoiesis). This leads to an excessive concentration of megakaryocyte intracytoplasmic components in the marrow intercellular space. Current concepts of marrow collagen regulation and megakaryocyte composition lend support to the hypothesis advocating… CONTINUE READING

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