Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies.

  title={Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies.},
  author={Kimberlee Burckart and Sorin G. Beca and Randall James Urban and Melinda Sheffield-Moore},
  journal={Current opinion in clinical nutrition and metabolic care},
  volume={13 4},
PURPOSE OF REVIEW Cancer-related muscle loss, or cachexia, is the cause of death for approximately 2 million people worldwide and severely reduces quality of life. The degree of cachexia is inversely correlated with survival time; however, the exact mechanisms behind cancer-induced muscle wasting remain under investigation. RECENT FINDINGS Cytokines such as tumor necrosis factor-alpha trigger degradatory pathways through nuclear factor-kappaB signaling that activate the ubiquitin-proteasome… CONTINUE READING


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