Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies.

@article{Burckart2010PathogenesisOM,
  title={Pathogenesis of muscle wasting in cancer cachexia: targeted anabolic and anticatabolic therapies.},
  author={Kimberlee Burckart and Sorin G. Beca and Randall James Urban and Melinda Sheffield-Moore},
  journal={Current opinion in clinical nutrition and metabolic care},
  year={2010},
  volume={13 4},
  pages={410-6}
}
PURPOSE OF REVIEW Cancer-related muscle loss, or cachexia, is the cause of death for approximately 2 million people worldwide and severely reduces quality of life. The degree of cachexia is inversely correlated with survival time; however, the exact mechanisms behind cancer-induced muscle wasting remain under investigation. RECENT FINDINGS Cytokines such as tumor necrosis factor-alpha trigger degradatory pathways through nuclear factor-kappaB signaling that activate the ubiquitin-proteasome… CONTINUE READING

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References

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New perspective on the nutritional approach to cancer - related anorexia / cachexia : preliminary results of a randomised phase III clinical trial with five different arms of treatment

FM Tanca, C Madeddu, A Macciò
Mediterr J Nutr Metab • 2009

Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology • 2008

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