Pathogenesis of murine gammaherpesvirus-68 infection in interleukin-6-deficient mice.

@article{Sarawar1998PathogenesisOM,
  title={Pathogenesis of murine gammaherpesvirus-68 infection in interleukin-6-deficient mice.},
  author={Sally R. Sarawar and James Weldon Brooks and Rhonda Diane Cardin and Mohammed Mehrpooya and Peter C. Doherty},
  journal={Virology},
  year={1998},
  volume={249 2},
  pages={
          359-66
        }
}
Murine gammaherpesvirus-68 (MHV-68) induces high levels of interleukin (IL)-6 production in both naive and primed lymphocyte populations. Mice that are homozygous (-/-) for deletion of the IL-6 gene were used to investigate the role of this cytokine in MHV-68 infection. The results showed that IL-6 is not essential for clearance of infectious MHV-68 from the lung or for the establishment, or control, of viral latency. Both IL-6 +/+ and -/- mice eliminated replicating virus from the respiratory… CONTINUE READING
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