Pathogenesis of mouse scrapie: patterns of agent replication in different parts of the CNS following intraperitoneal infection.

@article{Kimberlin1982PathogenesisOM,
  title={Pathogenesis of mouse scrapie: patterns of agent replication in different parts of the CNS following intraperitoneal infection.},
  author={Richard H. Kimberlin and Carol Anne Walker},
  journal={Journal of the Royal Society of Medicine},
  year={1982},
  volume={75 8},
  pages={
          618-24
        }
}
The dynamics of agent replication were studied at 8 levels of spinal cord and in 9 areas of brain of mice infected intraperitoneally with the 139A strain of scrapie agent. Replication in the CNS was first detectable at 2 levels of spinal cord between thoracic vertebrae 4 and 9. The onset of replication was progressively delayed by up to 4 weeks at increasingly lower levels of spinal cord. A similar trend was seen at higher levels of spinal cord and in brain. In brain, agent replication occurred… CONTINUE READING

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