Pathogenesis of migraine: role of neuromodulators.

  title={Pathogenesis of migraine: role of neuromodulators.},
  author={Giovanni D'Andrea and Antonello D'Arrigo and Maurizio Dalle Carbonare and Alberta Leon},
  volume={52 7},
The pathogenesis of migraine is still, today, a hotly debated issue. Recent biochemical studies report the occurrence in migraine of metabolic abnormalities in the synthesis of neurotransmitters and neuromodulators. These include a metabolic shift directing tyrosine metabolism toward the decarboxylation pathway, therein resulting in an unphysiological production of noradrenaline and dopamine along with increased synthesis of traces amines such as tyramine, octopamine, and synephrine. This… CONTINUE READING
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