Pathogenesis of membranous nephropathy: recent advances and future challenges

  title={Pathogenesis of membranous nephropathy: recent advances and future challenges},
  author={Pierre Ronco and Hanna Debiec},
  journal={Nature Reviews Nephrology},
Over the past few years, considerable advances have been made in our understanding of the molecular pathomechanisms of human membranous nephropathy, inspired by studies of Heymann nephritis, a faithful experimental model of this disease. This research led to the identification of neutral endopeptidase, the M-type receptor for secretory phospholipase A2 (PLA2R1) and cationic bovine serum albumin as target antigens of circulating and deposited antibodies in alloimmune neonatal, adult 'idiopathic… CONTINUE READING
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A case of phospholipase A2 receptor‐positive membranous nephropathy preceding sarcoid‐associated granulomatous tubulointerstitial nephritis

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